The TLE4 Monoclonal Antibody is a valuable tool for researchers studying the function of the TLE4 protein, a transcriptional corepressor involved in various cellular processes such as development, differentiation, and cell cycle regulation. This antibody, monoclonal in nature, is highly specific for human samples and is validated for use in immunohistochemistry applications. TLE4, a member of the Groucho/TLE family of proteins, is known to interact with various transcription factors and modulate gene expression in a context-dependent manner. Its role in regulating cell proliferation, differentiation, and apoptosis makes it a key player in developmental biology and cancer research.
By targeting the TLE4 protein, researchers can gain valuable insights into the mechanisms underlying these biological processes.In summary, the TLE4 Monoclonal Antibody is a reliable tool for studying the function and regulation of the TLE4 protein in various cellular contexts. Its specificity and validation for immunohistochemistry make it a valuable asset for researchers interested in understanding the role of TLE4 in development, differentiation, and disease.
Product Name:
TLE4 Monoclonal Antibody
SKU:
CAB23693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human TLE4 (NP_001269677).
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of beta-catenin-TCF complex.
Purification Method:
Affinity purification
Gene ID:
7091
Clone Number:
ARC61324
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TLE4 Rabbit mAb (CAB23693) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
