The TLE1 Rabbit Monoclonal Antibody (CAB3528) is a valuable tool for researchers studying TLE1, a transcriptional corepressor protein involved in various developmental processes, including cell fate determination and stem cell maintenance. This antibody, generated using rabbit monoclonal technology, is highly specific and sensitive for detecting TLE1 in human samples, making it ideal for use in immunohistochemistry and immunofluorescence applications.TLE1 is known for its role in repressing gene transcription by interacting with various transcription factors, such as TCF/LEF and Notch.
Dysregulation of TLE1 has been linked to various diseases, including cancer and developmental disorders. By using the TLE1 Rabbit Monoclonal Antibody, researchers can study the expression and localization of TLE1 in various tissue types, offering insights into its role in disease pathogenesis and potential therapeutic strategies targeting TLE1-mediated pathways.
Product Name:
TLE1 Rabbit Monoclonal Antibody
SKU:
CAB3528
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLE1 (Q04724).
Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex.
Purification Method:
Affinity purification
Gene ID:
7088
Clone Number:
ARC0793
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TLE1 Rabbit mAb (CAB3528) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
