The TLE1 Polyclonal Antibody (CAB5501) is a valuable tool for researchers studying the TLE1 protein, which is involved in various cellular processes including cell proliferation, differentiation, and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TLE1 is a transcriptional corepressor that plays a critical role in regulating gene expression and modulating signaling pathways involved in cell growth and differentiation. Dysregulation of TLE1 has been linked to various diseases, making it a promising target for research in areas such as cancer biology, developmental biology, and regenerative medicine.
This polyclonal antibody binds specifically to the TLE1 protein, allowing for accurate detection and analysis in different cell types and tissue samples. Its versatility and reliability make it an ideal choice for researchers seeking to better understand the molecular mechanisms underlying disease pathogenesis and identify potential therapeutic targets.
Product Name:
TLE1 Rabbit Polyclonal Antibody
SKU:
CAB5501
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 501-770 of human TLE1 (NP_005068.2).
Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex.
Purification Method:
Affinity purification
Gene ID:
7088
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of THP-1 cells, using TLE1 antibody (CAB5501) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
