The TKT1 Polyclonal Antibody (CAB15337) is an essential tool for researchers studying TKT1, a key enzyme involved in the pentose phosphate pathway. This antibody, derived from rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By binding to the TKT1 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an invaluable resource for studies in biochemistry, metabolism, and disease mechanisms.
TKT1 plays a crucial role in cellular metabolism by catalyzing the conversion of xylulose-5-phosphate and ribose-5-phosphate in the pentose phosphate pathway. Dysregulation of TKT1 has been implicated in cancer, diabetes, and other metabolic disorders, highlighting its importance as a potential therapeutic target. Understanding the function and regulation of TKT1 is essential for advancing research in these areas and uncovering new treatment strategies.
Product Name:
TKTL1 Rabbit Polyclonal Antibody
SKU:
CAB15337
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human TKTL1 (NP_036385.3).
The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TKTL1 Rabbit pAb (CAB15337) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
