The TK1 Polyclonal Antibody (CAB5612) is a valuable tool for researchers studying thymidine kinase 1 (TK1), an enzyme involved in DNA synthesis and cell proliferation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is specifically validated for use in immunohistochemistry and ELISA applications. By binding to the TK1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cancer biology and therapeutic development.TK1 is a key enzyme that plays a crucial role in DNA replication and repair, making it a potential target for cancer treatment and diagnosis. Elevated levels of TK1 have been associated with various types of cancer, making it a promising biomarker for early detection and monitoring of disease progression.
Research on TK1 can lead to the development of novel therapeutic strategies and personalized medicine approaches for cancer patients.In conclusion, the TK1 Polyclonal Antibody (CAB5612) is a reliable tool for studying TK1 and its implications in cancer biology. With its high specificity and sensitivity, this antibody offers researchers the opportunity to gain valuable insights into the role of TK1 in DNA synthesis and cell proliferation, ultimately contributing to the advancement of cancer research and therapeutic interventions.
Product Name:
Thymidine Kinase 1 Rabbit Polyclonal Antibody
SKU:
CAB5612
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 15-194 of human Thymidine Kinase 1 (NP_003249.3).
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers.
Purification Method:
Affinity purification
Gene ID:
7083
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Thymidine Kinase 1 Rabbit pAb (CAB5612) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
