The TJP2 Polyclonal Antibody (CAB0594) is a valuable tool for researchers studying TJP2, a protein involved in cell-cell adhesion and tight junction formation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to the TJP2 protein, this antibody enables the detection and analysis of TJP2 expression in various cell types, making it ideal for investigations in cell biology and epithelial barrier function.TJP2, also known as ZO-2, plays a crucial role in maintaining the integrity and function of tight junctions, which are critical for regulating the passage of molecules across cell layers.
Dysfunction of TJP2 has been implicated in various diseases, including cancer, inflammatory bowel disease, and neurological disorders. Therefore, understanding the role of TJP2 in tight junction regulation is essential for elucidating disease mechanisms and developing potential therapeutic strategies.Overall, the TJP2 Polyclonal Antibody (CAB0594) offers researchers a reliable tool for studying the function and expression of TJP2 in different physiological and pathological contexts, ultimately advancing our understanding of tight junction biology and its implications in human health and disease.
Product Name:
TJP2 Rabbit Polyclonal Antibody
SKU:
CAB0594
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 951-1190 of human TJP2 (NP_004808.2).
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
9414
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using TJP2 Rabbit pAb (CAB0594) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
