ZO-1 Rabbit Polyclonal Antibody (CAB0659)
- SKU:
- CAB0659
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | ZO-1 Rabbit Polyclonal Antibody |
SKU: | CAB0659 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-273 of human TJP1 (NP_003248.3). |
Sequence: | IWEQ HTVT LHRA PGFG FGIA ISGG RDNP HFQS GETS IVIS DVLK GGPA EGQL QEND RVAM VNGV SMDN VEHA FAVQ QLRK SGKN AKIT IRRK KKVQ IPVS RPDP EPVS DNEE DSYD EEIH DPRS GRSG VVNR RSEK IWPR DRSA SRER SLSP RSDR RSVA SSQP AKPT KVTL VKSR KNEE YGLR LASH IFVK EISQ DSLA ARDG NIQE GDVV LKIN GTVT ENMS LTDA KTLI ERSK GKLK MVVQ RDER ATLL NVPD |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | ZO-1 |
Positive Sample: | Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cytoplasmic side, Peripheral membrane protein, gap junction, tight junction. |
Calculated MW: | 195kDa |
Observed MW: | 195kDa |
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 7082 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |