TIRAP Rabbit Polyclonal Antibody (CAB12606)
- SKU:
- CAB12606
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | TIRAP Rabbit Polyclonal Antibody |
SKU: | CAB12606 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1). |
Sequence: | MASS TSLP APGS RPKK PLGK MADW FRQT LLKK PKKR PNSP ESTS SDAS QPTS QDSP LPPS LSSV TSPS LPPT HASD SGSS RWSK DYDV CVCH SEED LVAA QDLV SYLE GSTA SLRC FLQL RDAT PGGA IVSE LCQA LSSS HCRV LLIT PGFL QDPW CKYQ MLQA LTEA PGAE GCTI PLLS GLSR AAYP PELR FMYY VDGR GPDG GFRQ VKEA VMRY LQTL S |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | Mal; wyatt; BACTS1; MyD88-2; TIRAP |
Positive Sample: | HeLa,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Membrane. |
Calculated MW: | 24kDa |
Observed MW: | 32kDa |
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Purification Method: | Affinity purification |
Gene ID: | 114609 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |