The TIR Polyclonal Antibody (PACO50426) is a powerful tool for researchers studying Toll/interleukin-1 receptor (TIR) domain-containing proteins, which play essential roles in immune signaling pathways. This antibody, produced in rabbits, is highly specific to the TIR domain and has been validated for use in a variety of applications, including Western blot analysis.TIR domain-containing proteins are key players in the innate immune response, recognizing pathogens and initiating immune responses. The TIR Polyclonal Antibody binds specifically to the TIR domain, allowing for the detection and analysis of these important proteins in various cell types.
This makes it an ideal reagent for studies in immunology, infectious diseases, and inflammation research.By targeting the TIR domain, researchers can gain valuable insights into the mechanisms underlying immune signaling pathways and develop strategies to modulate immune responses. The TIR Polyclonal Antibody enables precise detection and characterization of TIR domain-containing proteins, facilitating advancements in our understanding of the immune system and the development of novel immunotherapies.
Antibody Name:
tir Antibody (PACO50426)
Antibody SKU:
PACO50426
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli O157:H7
Immunogen:
Recombinant Escherichia coli O157:H7 Translocated intimin receptor Tir protein (252-362AA)
Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion (By similarity).
Synonyms:
Translocated intimin receptor Tir (Secreted effector protein Tir), tir, espE
UniProt Protein Function:
Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion ().
