UniProt Protein Function: | TIPRL: May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. Belongs to the TIP41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 1q23.2Cellular Component: cytoplasm; intracellular membrane-bound organelleMolecular Function: protein bindingBiological Process: DNA damage checkpoint; negative regulation of protein phosphatase type 2A activity |
UniProt Protein Details: | |
NCBI Summary: | TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010] |
UniProt Code: | O75663 |
NCBI GenInfo Identifier: | 74739629 |
NCBI Gene ID: | 261726 |
NCBI Accession: | O75663.2 |
UniProt Secondary Accession: | O75663,Q5HYB2, Q8IZ86, B2R8V3 |
UniProt Related Accession: | O75663 |
Molecular Weight: | 20,214 Da |
NCBI Full Name: | TIP41-like protein |
NCBI Synonym Full Names: | TOR signaling pathway regulator |
NCBI Official Symbol: | TIPRLÂ Â |
NCBI Official Synonym Symbols: | TIP; TIP41; TIPRL1Â Â |
NCBI Protein Information: | TIP41-like protein |
UniProt Protein Name: | TIP41-like protein |
UniProt Synonym Protein Names: | Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP |
Protein Family: | TIP41-like protein |
UniProt Gene Name: | TIPRLÂ Â |
UniProt Entry Name: | TIPRL_HUMAN |