The TIPRL Polyclonal Antibody (PACO30410) is a valuable tool for researchers studying TIPRL, a protein involved in the regulation of immune responses. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to TIPRL, researchers can detect and analyze this protein in various cell types, making it ideal for studies in immunology and cancer research.TIPRL, also known as TIP41-like protein, is a key player in immune regulation, influencing pathways involved in inflammation and immune cell function.
Understanding the role of TIPRL is crucial in uncovering its potential as a therapeutic target in conditions such as cancer, autoimmune diseases, and inflammatory disorders. By utilizing the TIPRL Polyclonal Antibody, researchers can gain valuable insights into the biological functions of this protein and its implications in disease pathology.
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Synonyms:
TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP), TIPRL
UniProt Protein Function:
TIPRL: May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. Belongs to the TIP41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 1q23.2Cellular Component: cytoplasm; intracellular membrane-bound organelleMolecular Function: protein bindingBiological Process: DNA damage checkpoint; negative regulation of protein phosphatase type 2A activity
UniProt Protein Details:
NCBI Summary:
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
