The TINF2 Polyclonal Antibody (CAB6769) is a valuable tool for researchers studying TINF2, a key player in telomere maintenance and chromosome stability. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the TINF2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in aging, cancer, and genetic disorders.TINF2, a component of the shelterin complex, plays a crucial role in protecting chromosome ends and preserving genomic integrity.
Dysregulation of TINF2 has been linked to telomere dysfunction and genetic instability, highlighting its importance in cellular health and disease development. Research on TINF2 could provide valuable insights into aging-related disorders, cancer progression, and genetic syndromes, paving the way for the development of targeted therapies and interventions.
Product Name:
TIN2/TINF2 Rabbit Polyclonal Antibody
SKU:
CAB6769
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 202-451 of human TIN2/TIN2/TINF2 (NP_001092744.1).
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.
Purification Method:
Affinity purification
Gene ID:
26277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TIN2/TIN2/TINF2 antibody (CAB6769) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
