The TIMP3 Polyclonal Antibody (CAB1511) is a valuable tool for researchers studying tissue inhibitor of metalloproteinase 3 (TIMP3), a key regulator of extracellular matrix remodeling and cell signaling. This antibody, produced in rabbits, exhibits high specificity and sensitivity for TIMP3 in human samples, making it ideal for use in Western blot applications. By binding to TIMP3, this antibody enables the detection and analysis of TIMP3 expression in various cell types, providing insights into its role in physiology and disease.TIMP3 is a crucial player in maintaining tissue homeostasis and regulating processes such as angiogenesis, inflammation, and apoptosis.
Dysregulation of TIMP3 has been linked to various pathologies, including cancer, cardiovascular disease, and degenerative disorders. By studying the expression and activity of TIMP3, researchers can gain a deeper understanding of these diseases and potentially identify novel therapeutic targets.Overall, the TIMP3 Polyclonal Antibody (CAB1511) is a valuable tool for investigating the functions and dysregulation of TIMP3 in physiological and pathological conditions, with potential implications for the development of targeted therapies in various disease settings.
Product Name:
TIMP3 Rabbit Polyclonal Antibody
SKU:
CAB1511
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1).
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Purification Method:
Affinity purification
Gene ID:
7078
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat kidney, using TIMP3 antibody (CAB1511) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
