The TIMP3 Polyclonal Antibody (CAB11986) is a vital tool for researchers studying Tissue Inhibitor of Metalloproteinase 3 (TIMP3), a key player in the regulation of extracellular matrix remodeling and cell growth. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TIMP3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in the fields of cancer research and regenerative medicine.TIMP3 is a crucial inhibitor of metalloproteinases, enzymes that degrade the extracellular matrix.
Its role in controlling cell growth and tissue remodeling highlights its importance in various physiological and pathological processes, such as cancer metastasis and wound healing. Research on TIMP3 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies targeting TIMP3 activity. Overall, the TIMP3 Polyclonal Antibody (CAB11986) is a valuable tool for researchers aiming to deepen their understanding of TIMP3 function and its implications in human health and disease.
Product Name:
TIMP3 Rabbit Polyclonal Antibody
SKU:
CAB11986
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 110-210 of human TIMP3 (NP_000353.1).
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Purification Method:
Affinity purification
Gene ID:
7078
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat kidney, using TIMP3 antibody (CAB11986) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
