TIMP2 Rabbit Polyclonal Antibody (CAB16439)
- SKU:
- CAB16439
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TIMP2 Rabbit Polyclonal Antibody |
SKU: | CAB16439 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TIMP2 (NP_003246.1). |
Sequence: | VSLD VGGK KEYL IAGK AEGD GKMH ITLC DFIV PWDT LSTT QKKS LNHR YQMG CECK ITRC PMIP CYIS SPDE CLWM DWVT EKNI NGHQ AKFF ACIK RSDG S |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | DDC8; CSC-21K; TIMP2 |
Positive Sample: | Mouse testis,Mouse brain,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 24kDa |
Observed MW: | 22kDa |
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Purification Method: | Affinity purification |
Gene ID: | 7077 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |