The TIMP1 Rabbit Monoclonal Antibody (CAB4959) is a powerful tool for researchers studying Tissue Inhibitor of Metalloproteinase 1 (TIMP1), a protein involved in the regulation of extracellular matrix remodeling and tissue integrity. This antibody, produced in rabbits, exhibits high specificity and sensitivity for TIMP1 in human samples, making it ideal for use in a variety of experimental settings.TIMP1 is a key player in the control of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix and play crucial roles in processes such as wound healing, tissue remodeling, and cell migration. Dysregulation of TIMP1 and MMPs has been implicated in various diseases, including cancer, fibrosis, and cardiovascular disorders.
By targeting TIMP1 with this monoclonal antibody, researchers can gain valuable insights into the mechanisms underlying these pathological conditions.The TIMP1 Rabbit Monoclonal Antibody (CAB4959) is validated for use in techniques such as Western blotting, immunofluorescence, and immunohistochemistry, allowing for easy and reliable detection of TIMP1 in different experimental systems. Its specificity and sensitivity make it a valuable tool for investigating the role of TIMP1 in health and disease, paving the way for new therapeutic strategies targeting this important protein.
Product Name:
TIMP1 Rabbit Monoclonal Antibody
SKU:
CAB4959
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIMP1 (P01033).
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Purification Method:
Affinity purification
Gene ID:
7076
Clone Number:
ARC1195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HT-29 cells, using TIMP1 Rabbit mAb (CAB4959) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
