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TIMP1 Rabbit Monoclonal Antibody (CAB4959)

SKU:
CAB4959
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CLGI
EPA
EPO
HCI
TIMP
TIMP-1
Research Area:
Immunology
  • Immunology Antibodies 3 Anti-TIMP1 Antibody CAB4959
  • Immunology Antibodies 3 Anti-TIMP1 Antibody CAB4959
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TIMP1 Rabbit Monoclonal Antibody
SKU:CAB4959
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIMP1 (P01033).
Sequence:MAPF EPLA SGIL LLLW LIAP SRAC TCVP PHPQ TAFC NSDL VIRA KFVG TPEV NQTT LYQR YEIK MTKM YKGF QALG DAAD IRFV YTPA MESV CGYF HRSH
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:EPA; EPO; HCI; CLGI; TIMP; TIMP-1; TIMP1
Positive Sample:HT-29
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:23kDa
Observed MW:26kDa

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Purification Method:Affinity purification
Gene ID:7076
Clone Number:ARC1195
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of HT-29 cells, using TIMP1 Rabbit mAb (CAB4959) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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