The TIMP1 Polyclonal Antibody (CAB1389) is specifically designed for researchers studying tissue inhibitor of metalloproteinase 1 (TIMP1), a crucial protein involved in the regulation of extracellular matrix remodeling and tissue homeostasis. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.TIMP1 is a key player in the proteolytic balance within tissues, acting as an inhibitor of matrix metalloproteinases (MMPs) and influencing various physiological and pathological processes such as tissue repair, inflammation, and tumor progression. By targeting TIMP1 with this antibody, researchers can detect and analyze its expression in different cell types, providing valuable insights into its function and potential therapeutic implications in conditions like cancer, fibrosis, and cardiovascular diseases.
Understanding the role of TIMP1 in regulating extracellular matrix dynamics is essential for unraveling its impact on tissue remodeling and disease progression. This antibody serves as a valuable tool for investigating the intricate mechanisms underlying TIMP1-mediated processes, offering new avenues for exploring therapeutic strategies targeting TIMP1-related pathways.
Product Name:
TIMP1 Rabbit Polyclonal Antibody
SKU:
CAB1389
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 128-207 of human TIMP1 (NP_003245.1).
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Purification Method:
Affinity purification
Gene ID:
7076
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TIMP1 Rabbit pAb (CAB1389) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
