The TIMP1 Monoclonal Antibody (MACO0526) offered by AssayGenie is a valuable tool for researchers studying tissue inhibitors of metalloproteinases (TIMPs). This antibody specifically targets TIMP1, a key regulator of extracellular matrix remodeling and tissue homeostasis. Raised in mice, this monoclonal antibody is highly specific to human TIMP1 and has been validated for use in various applications, including Western blot and immunohistochemistry. It allows for the precise detection and analysis of TIMP1 protein levels in different cell and tissue types.TIMP1 is involved in numerous physiological and pathological processes, making it an important target for research in areas such as cancer, fibrosis, and cardiovascular diseases.
By understanding the role of TIMP1 in these conditions, researchers can develop targeted therapies to regulate extracellular matrix remodeling and tissue repair.Overall, the TIMP1 Monoclonal Antibody from AssayGenie is a reliable tool for investigating the functions of TIMP1 in health and disease, offering valuable insights into potential therapeutic strategies for various conditions.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Synonyms:
Timp-1
Immunohistochemistry of paraffin-embedded Rat prostate cancer using MACO0526 at dilution of 1:100.
UniProt Protein Function:
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
NCBI Summary:
acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling [RGD, Feb 2006]
