The TIMP1 Polyclonal Antibody (PACO33736) is a valuable tool for researchers studying tissue inhibitor of metalloproteinase 1 (TIMP1), a key player in extracellular matrix remodeling and cell signaling processes. This antibody, produced in rabbits, has high specificity for TIMP1 in human samples and has been validated for use in Western blot applications. By binding to the TIMP1 protein, it allows for precise detection and analysis in a variety of cell types, making it essential for studies in fields such as cancer research and tissue regeneration.TIMP1 is a critical regulator of matrix metalloproteinases (MMPs), enzymes involved in tissue remodeling processes such as wound healing and tumor invasion.
Dysregulation of TIMP1 has been linked to various diseases including cancer, cardiovascular disorders, and fibrotic conditions. Research into TIMP1 function is vital for understanding these pathologies and developing targeted therapies to combat them.By utilizing the TIMP1 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying TIMP1's involvement in disease progression and tissue remodeling processes. Its high specificity and reproducibility make it a reliable tool for investigating the role of TIMP1 in health and disease.
Antibody Name:
Timp1 Antibody (PACO33736)
Antibody SKU:
PACO33736
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Metalloproteinase inhibitor 1 protein (24-217AA)
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
NCBI Summary:
acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling [RGD, Feb 2006]
