Timp1 Antibody (PACO30402)
- SKU:
- PACO30402
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Timp1 Antibody (PACO30402)
The TIMP1 Polyclonal Antibody (PACO30402) is a valuable tool for researchers studying Tissue Inhibitor of Metalloproteinase 1 (TIMP1), a protein involved in regulating the activity of matrix metalloproteinases (MMPs) in various physiological and pathological processes. Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TIMP1, researchers can detect and analyze this protein in different cell types, making it an ideal choice for studies in areas such as immunology, cancer research, and tissue remodeling.
TIMP1 is known to play a key role in the balance between tissue remodeling and degradation, making it a target of interest in conditions such as cancer metastasis, cardiovascular diseases, and inflammatory disorders. By understanding the function and regulation of TIMP1, researchers can gain insights into potential therapeutic interventions aimed at modulating MMP activity and related processes.
| Antibody Name: | Timp1 Antibody (PACO30402) |
| Antibody SKU: | PACO30402 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Metalloproteinase inhibitor 1 protein (25-205AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. |
| Synonyms: | Metalloproteinase inhibitor 1 (Collagenase inhibitor 16C8 fibroblast) (Erythroid-potentiating activity) (EPA) (TPA-S1) (TPA-induced protein) (Tissue inhibitor of metalloproteinases 1) (TIMP-1), Timp1, Timp Timp-1 |
| UniProt Protein Function: | TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix Molecular Function:cytokine activity; enzyme inhibitor activity; growth factor activity; metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protease inhibitor activity Biological Process: cell activation; negative regulation of apoptosis; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; negative regulation of peptidase activity; positive regulation of cell proliferation; response to cytokine stimulus; response to hormone stimulus |
| UniProt Code: | P12032 |
| NCBI GenInfo Identifier: | 135851 |
| NCBI Gene ID: | 21857 |
| NCBI Accession: | P12032.2 |
| UniProt Secondary Accession: | P12032,P20064, Q61720, |
| UniProt Related Accession: | P12032 |
| Molecular Weight: | 22,628 Da |
| NCBI Full Name: | Metalloproteinase inhibitor 1 |
| NCBI Synonym Full Names: | tissue inhibitor of metalloproteinase 1 |
| NCBI Official Symbol: | Timp1Â Â |
| NCBI Official Synonym Symbols: | EPA; Clgi; Timp; TIMP-1; TPA-S1Â Â |
| NCBI Protein Information: | metalloproteinase inhibitor 1 |
| UniProt Protein Name: | Metalloproteinase inhibitor 1 |
| UniProt Synonym Protein Names: | Collagenase inhibitor 16C8 fibroblast; Erythroid-potentiating activity; EPA; TPA-S1; TPA-induced protein; Tissue inhibitor of metalloproteinases 1; TIMP-1 |
| Protein Family: | Metalloproteinase inhibitor |
| UniProt Gene Name: | Timp1Â Â |
| UniProt Entry Name: | TIMP1_MOUSE |
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