The TIMM8B Polyclonal Antibody (CAB15814) is a highly specific tool for research involving the translocase of inner mitochondrial membrane 8 homolog B (TIMM8B) protein. The antibody, raised in rabbits, is optimized for use in various experimental applications, including Western blotting and immunofluorescence microscopy. It binds specifically to TIMM8B, facilitating the detection and analysis of this important mitochondrial protein in different cell types.TIMM8B is a crucial component of the mitochondrial protein translocase complex, playing a key role in the import of nuclear-encoded proteins into the mitochondria. Dysregulation of TIMM8B has been linked to various mitochondrial disorders and neurodegenerative diseases.
Research on TIMM8B is essential for understanding mitochondrial function and its implications for human health.By using the TIMM8B Polyclonal Antibody, researchers can explore the function and localization of TIMM8B in cellular processes, shedding light on its involvement in mitochondrial biogenesis and maintenance. This antibody is a valuable tool for studies in biochemistry, cell biology, and mitochondrial disease research, providing insights into the molecular mechanisms underlying mitochondrial dysfunction.
Product Name:
TIMM8B Rabbit Polyclonal Antibody
SKU:
CAB15814
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 16-98 of human TIMM8B (NP_036591.1).
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.
Purification Method:
Affinity purification
Gene ID:
26521
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TIMM8B Rabbit pAb (CAB15814) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
