The TIMM8A Polyclonal Antibody (CAB9811) is a valuable tool for researchers studying the TIMM8A protein, which plays a crucial role in mitochondrial protein import. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TIMM8A protein, this antibody enables researchers to detect and analyze TIMM8A in a variety of cell types, making it ideal for studies in mitochondrial biology and related research areas.TIMM8A is a key component of the TIMM complex, responsible for importing nuclear-encoded proteins into the mitochondria.
Dysfunction of TIMM8A has been linked to various mitochondrial diseases, including deafness-dystonia syndrome and Mohr-Tranebjaerg syndrome. By studying the role of TIMM8A in mitochondrial protein import, researchers can gain valuable insights into these diseases and potentially identify new therapeutic targets for treatment.Overall, the TIMM8A Polyclonal Antibody is a valuable tool for researchers looking to investigate the function and role of TIMM8A in mitochondrial biology and disease. Its specificity and reliability make it a trusted choice for studies in this field.
Product Name:
TIMM8A Rabbit Polyclonal Antibody
SKU:
CAB9811
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human TIMM8A (NP_004076.1).
This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
1678
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of U-87MG, using TIMM8A Rabbit pAb (CAB9811) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
