The TIMM50 Polyclonal Antibody (CAB9991) is a valuable tool for researchers studying the TIMM50 protein, a key component of the mitochondrial import machinery involved in protein translocation into the mitochondria. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to TIMM50, this antibody enables accurate detection and analysis of the protein in various cell types, making it ideal for investigations in the fields of cell biology and mitochondrial function.TIMM50 is essential for the import of nuclear-encoded proteins into the mitochondria, playing a crucial role in maintaining mitochondrial homeostasis and overall cellular function.
Dysregulation of TIMM50 has been implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. Therefore, understanding the function and regulation of TIMM50 is essential for advancing research in these areas and developing targeted therapies.By utilizing the TIMM50 Polyclonal Antibody (CAB9991), researchers can gain valuable insights into the role of TIMM50 in cellular processes and disease pathology, ultimately contributing to the advancement of scientific knowledge and the development of novel treatment strategies.
Product Name:
TIMM50 Rabbit Polyclonal Antibody
SKU:
CAB9991
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-456 of human TIMM50 (NP_001001563.1).
This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis.
Purification Method:
Affinity purification
Gene ID:
92609
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TIMM50 antibody (CAB9991) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
