The TIMM44 Polyclonal Antibody (CAB17446) is a crucial tool for researchers studying TIMM44, a protein involved in mitochondrial import and assembly machinery. This antibody, derived from rabbit serum, is highly specific to human samples and has been validated for use in various applications, including Western blotting. By targeting the TIMM44 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it essential for studies in mitochondrial biology and related fields.TIMM44 plays a vital role in the import of proteins into the mitochondria, a process essential for proper mitochondrial function and cellular metabolism.
Dysregulation of TIMM44 has been implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. By understanding the functions and mechanisms of TIMM44, researchers can gain insight into these pathologies and potentially develop new therapeutic strategies to target mitochondrial dysfunction.Overall, the TIMM44 Polyclonal Antibody (CAB17446) is a valuable tool for researchers interested in unraveling the mysteries of mitochondrial import and its implications in health and disease. Its specificity and reliability make it an indispensable asset in the field of molecular biology and biomedicine.
Product Name:
TIMM44 Rabbit Polyclonal Antibody
SKU:
CAB17446
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 153-452 of human TIMM44 (NP_006342.2).
fibrillar center, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Calculated MW:
51kDa
Observed MW:
45kDa
This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma.
Purification Method:
Affinity purification
Gene ID:
10469
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TIMM44 Rabbit pAb (CAB17446) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
