The TIMM17B Polyclonal Antibody (CAB8477) is a crucial tool for researchers studying TIMM17B, a protein involved in mitochondrial import and assembly. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it suitable for use in various applications including Western blot and immunofluorescence.TIMM17B plays a vital role in mitochondrial protein import and assembly, essential processes for maintaining mitochondrial function and overall cell health. Dysregulation of TIMM17B has been linked to abnormalities in mitochondrial protein import and can result in mitochondrial dysfunction, impacting cellular energy production and metabolism.
Research on TIMM17B is critical for understanding its role in mitochondrial biology and its implications in various diseases such as neurodegenerative disorders, metabolic diseases, and cancer. By utilizing the TIMM17B Polyclonal Antibody, researchers can further investigate the functions and mechanisms of TIMM17B, leading to advancements in the development of targeted therapies and treatments for related diseases.
Product Name:
TIMM17B Rabbit Polyclonal Antibody
SKU:
CAB8477
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human TIMM17B (NP_005825.1).
This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10245
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse heart, using TIMM17B antibody (CAB8477) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
