Anti-TIMM17A Antibody (CAB13578)
- SKU:
- CAB13578
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-TIMM17A Antibody (CAB13578)
The TIMM17A Polyclonal Antibody (CAB13578) is for research purposes related to TIMM17A, a protein responsible for importing nuclear-encoded proteins into the mitochondria. This antibody is produced in rabbits and has high reactivity with human samples, making it suitable for use in Western blot applications. By binding to the TIMM17A protein, this antibody enables the detection and analysis of TIMM17A in various cell types, making it a valuable tool for studies in mitochondrial biology and related research areas.TIMM17A is a crucial component of the mitochondrial protein import machinery, essential for the proper function of mitochondria and cellular energy production.
Dysregulation of TIMM17A has been linked to various mitochondrial disorders, making it a promising target for studies on mitochondrial dysfunction and related diseases. Understanding the role of TIMM17A in protein transport and mitochondrial function is vital for advancing research in these areas and developing potential therapeutic interventions.If you have any further questions or would like to learn more about the TIMM17A Polyclonal Antibody, please feel free to contact us. Thank you for considering Assay Genie for your research needs.
| Antibody Name: | Anti-TIMM17A Antibody |
| Antibody SKU: | CAB13578 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-171 of human TIMM17A (NP_006326.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NCI-H460, HeLa, A-549, MCF7, HT-29, Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-171 of human TIMM17A (NP_006326.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEY AREP CPWR IVDD CGGA FTMG TIGG GIFQ AIKG FRNS PVGV NHRL RGSL TAIK TRAP QLGG SFAV WGGL FSMI DCSM VQVR GKED PWNS ITSG ALTG AILA ARNG PVAM VGSA AMGG ILLA LIEG AGIL LTRF ASAQ FPNG PQFA EDPS QLPS TQLP SSPF GDYR QYQ |
| Gene ID: | 10440 |
| Uniprot: | Q99595 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | TIMM17A, TIM17, TIM17A |
| Background: |
| UniProt Protein Function: | TIMM17A: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Belongs to the Tim17/Tim22/Tim23 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: mitochondrial inner membrane; integral to mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex Molecular Function:P-P-bond-hydrolysis-driven protein transmembrane transporter activity Biological Process: cellular protein metabolic process; protein targeting to mitochondrion |
| UniProt Code: | Q99595 |
| NCBI GenInfo Identifier: | 3219818 |
| NCBI Gene ID: | 10440 |
| NCBI Accession: | Q99595.1 |
| UniProt Secondary Accession: | Q99595,Q9BWF5, B2RDM5, |
| UniProt Related Accession: | Q99595 |
| Molecular Weight: | 171 |
| NCBI Full Name: | Mitochondrial import inner membrane translocase subunit Tim17-A |
| NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 17 homolog A (yeast) |
| NCBI Official Symbol: | TIMM17AÂ Â |
| NCBI Official Synonym Symbols: | TIM17; TIM17AÂ Â |
| NCBI Protein Information: | mitochondrial import inner membrane translocase subunit Tim17-A; preprotein translocase; mitochondrial inner membrane translocase; inner membrane preprotein translocase Tim17a |
| UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit Tim17-A |
| UniProt Synonym Protein Names: | Inner membrane preprotein translocase Tim17a |
| Protein Family: | Mitochondrial import inner membrane translocase |
| UniProt Gene Name: | TIMM17AÂ Â |
| UniProt Entry Name: | TI17A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TIMM17A antibody (CAB13578) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using TIMM17A antibody (CAB13578) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using TIMM17A antibody (CAB13578). Blue: DAPI for nuclear staining. |
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