The Timeless Polyclonal Antibody (CAB0512) is a valuable tool for researchers studying the Timeless protein, a key player in DNA damage response and circadian rhythm regulation. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding to the Timeless protein, this antibody enables precise detection and analysis in different cell types, making it an ideal choice for studies in genetics, cell biology, and chronobiology.
Timeless, a conserved protein involved in DNA replication and repair, is essential for maintaining genome stability and ensuring proper cell division. Its role in regulating circadian rhythms and coordinating cellular processes makes it a critical target for research on disorders like cancer, neurodegenerative diseases, and sleep disorders. Understanding the function of Timeless is crucial for developing targeted treatments and interventions that can restore cellular homeostasis and prevent disease progression.
Product Name:
Timeless Rabbit Monoclonal Antibody
SKU:
CAB0512
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1058-1208 of human Timeless (Q9UNS1).
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.
Purification Method:
Affinity purification
Gene ID:
8914
Clone Number:
ARC1827
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Timeless Rabbit mAb (CAB0512) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
