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TIE1 Rabbit Polyclonal Antibody (CAB3334)

SKU:
CAB3334
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular
€139 - €419
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Description

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Product Name:TIE1 Rabbit Polyclonal Antibody
SKU:CAB3334
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human TIE1 (NP_005415.1).
Sequence:IPQI LNMA SELE FNLE TMPR INCA AAGN PFPV RGSI ELRK PDGT VLLS TKAI VEPE KTTA EFEV PRLV LADS GFWE CRVS TSGG QDSR RFKV NVKV PPVP LAAP RLLT KQSR QLVV SPLV SFSG DGPI STVR LHYR PQDS TMDW STIV VDPS ENVT LMNL RPKT GYSV RVQL SRPG EGGE GAWG PPTL MTTD CPEP LLQP WLEG WHVE GTDR LRVS WSLP LVPG PLVG DGFL LRLW DGTR GQER RENV SSP
Tested Applications:WB ELISA
Recommended Dilution:WB,1:200 - 1:2000
Synonyms:TIE; JTK14; LMPHM11; TIE1
Positive Sample:MCF-7,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:125kDa
Observed MW:135/140kDa

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Purification Method:Affinity purification
Gene ID:7075
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using TIE1 Rabbit pAb (CAB3334) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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