The TICAM1 Polyclonal Antibody (CAB13605) is a valuable tool for researchers studying TICAM1, a vital protein involved in innate immune responses. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the TICAM1 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies focusing on immunology and infectious diseases.TICAM1, also known as Toll/interleukin-1 receptor domain-containing adapter molecule 1, plays a crucial role in the activation of the innate immune system in response to microbial infections.
Its role in triggering signaling pathways leading to the production of inflammatory cytokines and interferons makes it a key target for research in infectious diseases, sepsis, and autoimmune conditions. Understanding the function of TICAM1 is essential for developing therapeutics that target the innate immune response in various disease contexts.Overall, the TICAM1 Polyclonal Antibody (CAB13605) provides researchers with a reliable tool for investigating the role of TICAM1 in the immune response and its implications for disease pathogenesis and treatment strategies.
Product Name:
TICAM1 Rabbit Polyclonal Antibody
SKU:
CAB13605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human TRIF/TICAM1 (NP_891549.1).
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced.
Purification Method:
Affinity purification
Gene ID:
148022
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRIF/TICAM1 Rabbit pAb (CAB13605) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
