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TIAM1 Rabbit Polyclonal Antibody (CAB10252)

SKU:
CAB10252
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-TIAM1 Antibody CAB10252
  • Cell Biology Antibodies 1 Anti-TIAM1 Antibody CAB10252
  • Cell Biology Antibodies 1 Anti-TIAM1 Antibody CAB10252
€139 - €419

Description

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TIAM1 Rabbit Polyclonal Antibody (CAB10252)

The TIAM1 Polyclonal Antibody (CAB10252) is a valuable tool for researchers studying the TIAM1 protein, which is involved in cell signaling pathways regulating cell growth, migration, and invasion. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TIAM1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in cancer research and cell biology.

TIAM1, also known as T-lymphoma invasion and metastasis-inducing protein 1, plays a crucial role in cell adhesion, migration, and invasion processes. Its involvement in cancer progression and metastasis makes it a promising target for understanding tumor biology and developing targeted therapies. By elucidating the mechanisms by which TIAM1 functions in these processes, researchers can gain insights into potential therapeutic strategies for cancer treatment.

Product Name:TIAM1 Rabbit Polyclonal Antibody
SKU:CAB10252
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1392-1591 of human TIAM1 (NP_003244.2).
Sequence:SILR DKHR RQLL KTES LPSS QQYV PFGG KRLC ALKG ARPA MSRA VSAP SKSL GRRR RRLA RNRF TIDS DAVS ASSP EKES QQPP GGGD TDRW VEEQ FDLA QYEE QDDI KETD ILSD DDEF CESV KGAS VDRD LQER LQAT SISQ RERG RKTL DSHA SRMA QLKK QAAL SGIN GGLE SASE EVIW VRRE DFAP SRKL NTEI
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:NEDLDS; TIAM-1; TIAM1
Positive Sample:Rat testis
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Cytoplasmic side, Peripheral membrane protein.
Calculated MW:178kDa
Observed MW:250kDa

This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain.

Purification Method:Affinity purification
Gene ID:7074
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Rat testis, using TIAM1 Rabbit pAb (CAB10252) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.

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