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TIA1 Rabbit Polyclonal Antibody (CAB12523)

SKU:
CAB12523
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-TIA1 Antibody CAB12523
  • Cell Death Antibodies 1 Anti-TIA1 Antibody CAB12523
  • Cell Death Antibodies 1 Anti-TIA1 Antibody CAB12523
  • Cell Death Antibodies 1 Anti-TIA1 Antibody CAB12523
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TIA1 Rabbit Polyclonal Antibody
SKU:CAB12523
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 287-386 of human TIA1 (NP_071505.2).
Sequence:TLDM INPV QQQN QIGY PQPY GQWG QWYG NAQQ IGQY MPNG WQVP AYGM YGQA WNQQ GFNQ TQSS APWM GPNY GVQP PQGQ NGSM LPNQ PSGY RVAG YETQ
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:WDM; ALS26; TIA-1; TIA1
Positive Sample:Jurkat
Conjugate:Unconjugated
Cellular Localization:Cytoplasmic granule, Nucleus.
Calculated MW:43kDa
Observed MW:44kDa

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene.

Purification Method:Affinity purification
Gene ID:7072
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of Jurkat, using TIA1 Rabbit pAb (CAB12523) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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