The TIA1 Polyclonal Antibody (CAB12523) is a valuable tool for researchers studying TIA1, a RNA-binding protein involved in regulating RNA splicing and translation. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in Western blot applications. By binding to the TIA1 protein, this antibody allows for the detection and analysis of TIA1 in various cell types, making it ideal for studies in molecular biology, RNA metabolism, and neurodegenerative diseases.
TIA1 is a crucial player in the post-transcriptional regulation of gene expression, influencing processes such as alternative splicing and mRNA localization. Dysregulation of TIA1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Understanding the role of TIA1 in these contexts is essential for unraveling the mechanisms underlying disease pathology and identifying potential therapeutic targets.
Product Name:
TIA1 Rabbit Polyclonal Antibody
SKU:
CAB12523
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 287-386 of human TIA1 (NP_071505.2).
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7072
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Jurkat, using TIA1 Rabbit pAb (CAB12523) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
