The TIA1 Polyclonal Antibody (CAB12517) is a vital tool for research involving TIA1, a key RNA-binding protein involved in regulating alternative splicing and mRNA translation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TIA1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology, RNA biology, and cell signaling pathways.TIA1 is known for its role in modulating RNA metabolism and stress responses within cells, making it a crucial player in processes such as immune response, cell survival, and apoptosis.
Its involvement in these pathways highlights its potential significance in various diseases, including cancer, neurodegenerative disorders, and immune system dysregulation. Investigating the functions of TIA1 can provide valuable insights into disease mechanisms and potential therapeutic targets, ultimately advancing our understanding of cellular processes and disease pathology.
Product Name:
TIA1 Rabbit Polyclonal Antibody
SKU:
CAB12517
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 287-386 of human TIA1 (NP_071505.2).
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7072
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TIA1 Rabbit pAb (CAB12517) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
