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Thyroid Hormone Receptor alpha Transcription Factor Activity Assay

SKU:
TFAB00173
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Thyroid Hormone Receptor alpha
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet

Thyroid Hormone Receptor alpha Transcription Factor Activity Assay

The Thyroid Hormone Receptor Alpha Transcription Factor Activity Assay Kit is a highly sensitive and specific assay designed for the accurate measurement of thyroid hormone receptor alpha activity in various biological samples. This kit provides researchers with reliable and reproducible results, making it an essential tool for studying the role of thyroid hormone receptor alpha in gene transcription and cellular processes. Thyroid hormone receptor alpha is a key transcription factor that regulates the expression of genes involved in metabolism, growth, and development. Dysregulation of thyroid hormone receptor alpha activity has been implicated in a variety of diseases, including thyroid disorders, metabolic disorders, and certain types of cancer.

By measuring thyroid hormone receptor alpha activity, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets. Whether you are studying thyroid biology, metabolism, or the development of novel therapeutics, the Thyroid Hormone Receptor Alpha Transcription Factor Activity Assay Kit provides a versatile and reliable solution for your research needs. Upgrade your experiments with this advanced assay kit and unlock new possibilities in thyroid hormone receptor alpha research.

Product Name:Thyroid Hormone Receptor alpha Transcription Factor Activity Assay
Product Code:TFAB00173
Target:Thyroid Hormone Receptor alpha
Synonyms:Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, EAR-7, c-erbA-1, c-erbA-alpha
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie Thyroid Hormone Receptor alpha transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.
UniProt Protein Details:

Protein type:DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function:protein domain specific binding; protein binding; zinc ion binding; sequence-specific DNA binding; TATA-binding protein binding; chromatin DNA binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; ossification; cytoplasmic sequestering of transcription factor; intracellular receptor-mediated signaling pathway; hormone-mediated signaling; positive regulation of female receptivity; regulation of myeloid cell apoptosis; regulation of lipid catabolic process; regulation of heart contraction; regulation of transcription from RNA polymerase II promoter; female courtship behavior; learning and/or memory; thyroid gland development; erythrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to cold; negative regulation of transcription, DNA-dependent; cartilage condensation

Disease: Hypothyroidism, Congenital, Nongoitrous, 6

NCBI Summary:The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P10827
NCBI GenInfo Identifier:135705
NCBI Gene ID:7067
NCBI Accession:P10827.1
UniProt Secondary Accession:P10827,P21205, Q8N6A1, Q96H73, A8K3B5,
UniProt Related Accession:P10827
Molecular Weight:50,465 Da
NCBI Full Name:Thyroid hormone receptor alpha
NCBI Synonym Full Names:thyroid hormone receptor, alpha
NCBI Official Symbol:THRA  
NCBI Official Synonym Symbols:AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1  
NCBI Protein Information:thyroid hormone receptor alpha; EAR-7; c-erbA-alpha; ERBA-related 7; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
UniProt Protein Name:Thyroid hormone receptor alpha
UniProt Synonym Protein Names:Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha
Protein Family:Thyroid hormone receptor
UniProt Gene Name:THRA  
UniProt Entry Name:THA_HUMAN
AntibodiesELISA Kits
Anti-THRA Antibody (CAB5592)Human THR alpha (Thyroid Hormone Receptor Alpha) CLIA Kit (HUES01258)
THRA Antibody (PACO05205)
THRA Antibody (PACO12744)
THRA Antibody (PACO17238)
THRA Antibody (PACO23140)

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