The THTPA Polyclonal Antibody (PACO12745) is a key tool for researchers studying THTPA, a crucial enzyme involved in thiamine metabolism. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blotting. By binding to the THTPA protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for research in biochemistry and metabolism.
THTPA is essential for the conversion of thiamine into its active form, thiamine pyrophosphate, which plays a critical role in cellular energy production. Dysregulation of THTPA activity has been linked to thiamine deficiency-related diseases, such as Wernicke-Korsakoff syndrome and maple syrup urine disease. Research into the function and regulation of THTPA is vital for understanding these disorders and developing potential treatments or interventions to mitigate their effects.
THTP: Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family.Protein type: Cofactor and Vitamin Metabolism - thiamine; EC 3.6.1.28; HydrolaseChromosomal Location of Human Ortholog: 14q11.2Cellular Component: cytosolMolecular Function: hydrolase activity; magnesium ion binding; thiamin-triphosphatase activityBiological Process: dephosphorylation; thiamin and derivative metabolic process; thiamin diphosphate metabolic process; thiamin metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
