The Thrombomodulin Polyclonal Antibody (CAB4155) is a vital tool for researchers studying thrombomodulin, a protein involved in blood coagulation and inflammation regulation. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in Western blot assays. By binding to thrombomodulin, this antibody allows for precise detection and analysis in various cell types, making it a valuable asset for studies in immunology and cardiovascular research.
Thrombomodulin is a key player in maintaining hemostasis and preventing excessive blood clotting, as well as in modulating inflammatory responses. Its role in regulating coagulation and inflammation makes it a promising target for research on conditions such as thrombosis, sepsis, and cardiovascular disorders. Understanding the function of thrombomodulin is crucial for developing therapeutic strategies that target these diseases by manipulating the balance of coagulation and inflammation in the body.
Product Name:
THBD Rabbit Polyclonal Antibody
SKU:
CAB4155
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-515 of human CD141/Thrombomodulin (NP_000352.1).
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Purification Method:
Affinity purification
Gene ID:
7056
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using CD141/Thrombomodulin Rabbit pAb (CAB4155) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
