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Anti-THRB Antibody (CAB1582)

SKU:
CAB1582
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-THRB Antibody CAB1582
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-THRB Antibody CAB1582
€139 - €419
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Description

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Anti-THRB Antibody (CAB1582)

The THRB Polyclonal Antibody (CAB1582) is specifically designed for research involving the THRB protein, a crucial component of thyroid hormone signaling pathways. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.THRB, also known as thyroid hormone receptor beta, is essential for the regulation of metabolism, growth, and development in the body. Dysregulation of THRB signaling has been linked to thyroid disorders, metabolic diseases, and even certain types of cancers.

By using this antibody, researchers can accurately detect and analyze the expression of THRB in different cell types, providing valuable insights into its role in various physiological and pathological processes.The THRB Polyclonal Antibody is a valuable tool for studies in endocrinology, metabolism, and cancer research. Its high specificity and reliability make it an ideal choice for researchers looking to investigate the function and regulation of THRB in health and disease.

Antibody Name:Anti-THRB Antibody
Antibody SKU:CAB1582
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human THRB (NP_000452.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, U-87MG, Mouse liver, Mouse eye, Rat liver, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human THRB (NP_000452.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTPN SMTE NGLT AWDK PKHC PDRE HDWK LVGM SEAC LHRK SHSE RRST LKNE QSSP HLIQ TTWT SSIF HLDH DDVN DQSV SSAQ TFQT EEKK CKGY IPSY LDKD ELCV VCGD KATG YHYR CITC EGCK GFFR RTIQ KNLH PSYS CKYE GKCV IDKV TRNQ CQEC RFKK CIYV GMAT DLVL DDSK RLAK RKLI EENR EKRR REEL QKSI GHKP EPTD EEWE LIKT VTEA HVAT NAQG SHWK QKRK FLPE DI
Gene ID:7068
Uniprot:P10828
Cellular Location:Nucleus
Calculated MW:52kDa/54kDa
Observed MW:53kDa
Synonyms:THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
Background:The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
UniProt Protein Function:TR-beta1: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Homolog of the viral oncogene erbB. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; nuclear chromatin; nucleus

Molecular Function:protein binding; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; chromatin DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription corepressor activity; transcription factor activity

Biological Process: negative regulation of female receptivity; transcription initiation from RNA polymerase II promoter; organ morphogenesis; sensory perception of sound; intracellular receptor-mediated signaling pathway; female courtship behavior; transcription, DNA-dependent; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction

Disease: Thyroid Hormone Resistance, Selective Pituitary; Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive

NCBI Summary:The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P10828
NCBI GenInfo Identifier:586092
NCBI Gene ID:7068
NCBI Accession:P10828.2
UniProt Secondary Accession:P10828,P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41, B3KU79
UniProt Related Accession:P10828
Molecular Weight:461
NCBI Full Name:Thyroid hormone receptor beta
NCBI Synonym Full Names:thyroid hormone receptor, beta
NCBI Official Symbol:THRB  
NCBI Official Synonym Symbols:GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA  
NCBI Protein Information:thyroid hormone receptor beta; oncogene ERBA2; nuclear receptor subfamily 1 group A member 2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
UniProt Protein Name:Thyroid hormone receptor beta
UniProt Synonym Protein Names:Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
Protein Family:Thyroid hormone receptor
UniProt Gene Name:THRB  
UniProt Entry Name:THB_HUMAN
Anti-THRB Antibody (CAB1582)Western blot analysis of extracts of various cell lines, using THRB antibody (CAB1582) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-THRB Antibody (CAB1582)Immunofluorescence analysis of U-2 OS cells using THRB antibody (CAB1582) at dilution of 1:100. Blue: DAPI for nuclear staining.

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