The THRA Polyclonal Antibody (CAB5592) is a valuable tool for research involving THRA, a key transcription factor involved in thyroid hormone signaling. This antibody, produced in rabbits, shows high reactivity with human THRA samples and is suitable for use in applications such as Western blotting. By selectively binding to the THRA protein, researchers can effectively study its role in regulating gene expression and physiological processes in various cell types.THRA is essential for thyroid hormone signaling, which plays a critical role in the regulation of metabolism, development, and growth.
Dysregulation of THRA function has been linked to various diseases, including thyroid disorders, metabolic diseases, and certain types of cancer. Investigating the mechanisms by which THRA influences gene expression and cellular function is crucial for understanding these conditions and developing targeted therapies.Overall, the THRA Polyclonal Antibody offers researchers a reliable tool for studying the role of THRA in health and disease, providing valuable insights into thyroid hormone signaling pathways and potential therapeutic strategies.
Product Name:
THRA Rabbit Polyclonal Antibody
SKU:
CAB5592
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 138-180 of human THRA (NP_003241.2).
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
7067
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using THRA Rabbit pAb (CAB5592) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
