Thpo Antibody (PACO32440)
- SKU:
- PACO32440
- Product Type:
- Antibody
- Reactivity:
- Rat
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Thpo Antibody (PACO32440)
The THPO Polyclonal Antibody (PAC032440) is a valuable tool for researchers studying the THPO protein, also known as thrombopoietin. This antibody, generated in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.THPO is a critical regulator of platelet production and megakaryocyte differentiation, making it a key player in hematopoiesis and thrombopoiesis. Dysregulation of THPO has been linked to various hematological disorders, including thrombocytopenia and myeloproliferative neoplasms.
By targeting THPO with this antibody, researchers can investigate its role in these diseases and develop targeted therapies for patients.Overall, the THPO Polyclonal Antibody is a vital tool for researchers in the fields of hematology and oncology, enabling them to unravel the complex mechanisms of THPO and its implications for various blood-related disorders.
| Antibody Name: | Thpo Antibody (PACO32440) |
| Antibody SKU: | PACO32440 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Mouse, Human |
| Immunogen: | Recombinant Rat Thrombopoietin protein (22-194AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Thpo antibody at 4µg/ml Lane 1: Mouse liver tissue Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa . |
| Background: | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Synonyms: | Thrombopoietin, Thpo |
| UniProt Protein Function: | THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:hormone activity; cytokine activity; receptor binding Biological Process: cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of cell proliferation; response to lipopolysaccharide; myeloid cell differentiation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation |
| UniProt Code: | P49745 |
| NCBI GenInfo Identifier: | 1730007 |
| NCBI Gene ID: | 103690065 |
| NCBI Accession: | P49745.1 |
| Molecular Weight: | 34,556 Da |
| NCBI Full Name: | Thrombopoietin |
| NCBI Synonym Full Names: | thrombopoietin |
| NCBI Official Symbol: | LOC103690065Â Â |
| NCBI Protein Information: | thrombopoietin |
| UniProt Protein Name: | Thrombopoietin |
| Protein Family: | Thyroid peroxidase |
| UniProt Gene Name: | Thpo  |
| UniProt Entry Name: | TPO_RAT |
Related Products
Human Thrombopoietin (THPO) ELISA Kit (HUEB0157)
Mouse Thrombopoietin (Thpo) ELISA Kit (MOEB0129)
Dog Thrombopoietin (THPO) ELISA Kit (CNEB0045)
Rat Thrombopoietin (Thpo) ELISA Kit (RTEB0106)
