The THOC3 Polyclonal Antibody (CAB13230) is specifically designed for research involving THOC3, a key protein involved in mRNA export from the nucleus to the cytoplasm. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the THOC3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in molecular biology and gene expression regulation.THOC3 is a crucial component of the TREX complex, which mediates the export of processed mRNA transcripts.
Its role in mRNA export makes it a valuable target for research exploring gene expression control, RNA processing, and cellular signaling pathways. By understanding the function of THOC3, researchers can gain insights into various biological processes and potentially uncover new therapeutic targets for conditions related to aberrant gene expression.Overall, the THOC3 Polyclonal Antibody is a reliable tool for investigating the role of THOC3 in mRNA export and gene regulation, offering valuable insights into molecular mechanisms that govern cellular function.
Product Name:
THOC3 Rabbit Polyclonal Antibody
SKU:
CAB13230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human THOC3 (NP_115737.1).
This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5.
Purification Method:
Affinity purification
Gene ID:
84321
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using THOC3 Rabbit pAb (CAB13230) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
