The THNSL2 Polyclonal Antibody (PACO59213) is a valuable tool for researchers studying the THNSL2 protein, which plays a crucial role in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the THNSL2 protein, this antibody enables accurate detection and analysis in a range of cell types, making it an essential component for studies in molecular biology and disease research.THNSL2 is a protein involved in RNA processing and gene expression regulation, making it a key player in maintaining cellular homeostasis. Dysfunction of THNSL2 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance as a potential therapeutic target.
By elucidating the role of THNSL2 in these conditions, researchers can gain valuable insights that may lead to the development of targeted treatments and interventions.Overall, the THNSL2 Polyclonal Antibody is a versatile tool for investigating the function and regulation of THNSL2 in health and disease. Its specificity and reliability make it an indispensable resource for researchers seeking to deepen their understanding of this critical protein and its implications for human health.
Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate. All lanes: THNSL2 antibody at 4.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55, 46, 43, 48, 28 kDa. Observed band size: 55 kDa.
IHC image of PACO59213 diluted at 1:400 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
