The THEM4 Polyclonal Antibody (CAB15940) is a vital tool for researchers studying THEM4, a protein involved in metabolic regulation and inflammation. The antibody, produced in rabbits, has high specificity for THEM4 in human samples and is validated for use in Western blot applications. It allows for accurate detection and analysis of THEM4 protein levels in various cell types, making it perfect for investigations in metabolic disorders, obesity, and inflammation-related diseases.
THEM4, a member of the protein kinase family, plays a crucial role in regulating lipid metabolism and glucose homeostasis. Its functions in insulin signaling and inflammation make it a promising target for research on metabolic diseases and chronic inflammatory conditions. Understanding the role of THEM4 in cellular processes is essential for developing targeted therapies that manipulate metabolic pathways and inflammatory responses for the treatment of these diseases.
Product Name:
THEM4 Rabbit Polyclonal Antibody
SKU:
CAB15940
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 37-150 of human THEM4 (NP_444283.2).
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.
Purification Method:
Affinity purification
Gene ID:
117145
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using THEM4 Rabbit pAb (CAB15940) at 1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
