Thbs1 Antibody (PACO30370)
- SKU:
- PACO30370
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Thbs1 Antibody (PACO30370)
The THBS1 Polyclonal Antibody (PAC030370) is a valuable tool for research involving THBS1, a protein that plays a crucial role in cell adhesion, migration, and signal transduction. This antibody, produced in rabbits, is highly specific for human THBS1 and has been validated for use in various applications, including Western blot and immunohistochemistry.THBS1, also known as thrombospondin-1, is a multi-functional protein that is involved in processes such as angiogenesis, inflammation, and wound healing. Its dysregulation has been linked to various diseases, including cancer, cardiovascular diseases, and fibrosis.
By using the THBS1 Polyclonal Antibody, researchers can explore the expression and function of THBS1 in different biological contexts, furthering our understanding of its role in health and disease.Overall, the THBS1 Polyclonal Antibody is a reliable tool for studying THBS1 and its implications in various physiological and pathological processes. Its high specificity and sensitivity make it a valuable asset for researchers in fields such as immunology, oncology, and cardiovascular research.
| Antibody Name: | Thbs1 Antibody (PACO30370) |
| Antibody SKU: | PACO30370 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Thrombospondin-1 protein (19-350AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties |
| Synonyms: | Thrombospondin-1, Thbs1, Tsp1 |
| UniProt Protein Function: | THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family. |
| UniProt Protein Details: | Protein type:Inhibitor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2 E5|2 59.34 cM Cellular Component: cell surface; cytoplasm; endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular space; fibrinogen complex; sarcoplasmic reticulum; secretory granule Molecular Function:extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; heparin binding; integrin binding; laminin binding; low-density lipoprotein binding; phosphatidylserine binding; protein binding; transforming growth factor beta binding Biological Process: activation of MAPK activity; behavioral response to pain; blood vessel morphogenesis; cell cycle arrest; cell migration; engulfment of apoptotic cell; inflammatory response; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptosis; negative regulation of blood vessel endothelial cell migration; negative regulation of caspase activity; negative regulation of cell-matrix adhesion; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of interleukin-12 production; peptide cross-linking; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of macrophage activation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; regulation of cGMP metabolic process; response to calcium ion; response to glucose stimulus; response to magnesium ion; response to mechanical stimulus; sprouting angiogenesis |
| NCBI Summary: | The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P35441 |
| NCBI GenInfo Identifier: | 549134 |
| NCBI Gene ID: | 21825 |
| NCBI Accession: | P35441.1 |
| UniProt Related Accession: | P35441 |
| Molecular Weight: | |
| NCBI Full Name: | Thrombospondin-1 |
| NCBI Synonym Full Names: | thrombospondin 1 |
| NCBI Official Symbol: | Thbs1Â Â |
| NCBI Official Synonym Symbols: | TSP1; TSP-1; tbsp1; Thbs-1Â Â |
| NCBI Protein Information: | thrombospondin-1 |
| UniProt Protein Name: | Thrombospondin-1 |
| Protein Family: | Thrombospondin |
| UniProt Gene Name: | Thbs1Â Â |
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