The THAP9 Polyclonal Antibody (PAC020677) is a valuable tool for researchers studying THAP9, a member of the THAP (Thanatos-associated protein) family of proteins involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.THAP9 plays a role in gene regulation, DNA binding, and cell cycle control, making it an important target for investigation in the fields of genetics and molecular biology. By binding specifically to THAP9 protein, this antibody allows for the detection and analysis of THAP9 in different cell types, providing researchers with valuable insights into its function and potential implications in diseases.
Given the diverse functions of THAP9, including its involvement in transcriptional regulation and cell proliferation, studying this protein has the potential to advance our understanding of various biological processes and diseases. The THAP9 Polyclonal Antibody is a reliable tool for researchers looking to explore the role of THAP9 in cellular pathways and its potential as a therapeutic target in conditions such as cancer and developmental disorders.
Antibody Name:
THAP9 Antibody (PACO20677)
Antibody SKU:
PACO20677
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human THAP9
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20677(THAP9 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
THAP9 (THAP domain-containing protein 9) is a 903 amino acid, protein that contains one THAP-type zinc finger. The gene that encodes THAP9 contains roughly 19,448 bases and maps to human chromosome 4q21.22. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acid, mia and polycystic kidney disease.
Synonyms:
THAP domain containing 9
UniProt Protein Function:
THAP9: Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transpositionChromosomal Location of Human Ortholog: 4q21.22Molecular Function: transferase activity; sequence-specific DNA binding; metal ion binding; transposase activityBiological Process: DNA integration; transposition, DNA-mediated; DNA recombination
