The THAP1 Polyclonal Antibody (CAB7472) is specifically designed for researchers studying THAP1, a transcription factor associated with neurological disorders such as dystonia and Parkinson's disease. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blotting.THAP1 is a crucial protein involved in regulating gene expression and has been linked to various neurological conditions. By targeting THAP1 with this antibody, researchers can effectively detect and study the protein in different cell types, providing valuable insights into the molecular mechanisms underlying these diseases.
Given the importance of THAP1 in neurological disorders, this antibody is an essential tool for studying the role of THAP1 in disease progression and potential therapeutic interventions. Its specificity and reliability make it an ideal choice for researchers in the fields of neurology and molecular biology looking to further our understanding of these complex conditions.
Product Name:
THAP1 Rabbit Polyclonal Antibody
SKU:
CAB7472
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human THAP1 (NP_060575.1).
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
55145
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using THAP1 antibody (CAB7472) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
