The TH Polyclonal Antibody (CAB12756) is a vital tool for researchers studying TH, a key protein involved in immune regulation and the inflammatory response. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TH protein, this antibody facilitates the detection and analysis of TH in a variety of cell types, making it an essential resource for investigations in immunology, inflammation, and related fields.TH, also known as tyrosine hydroxylase, plays a crucial role in the synthesis of neurotransmitters and catecholamines, making it a valuable target for research on neurological disorders, psychiatric conditions, and neurodegenerative diseases.
By understanding the function and regulation of TH, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.Overall, the TH Polyclonal Antibody (CAB12756) serves as a powerful tool for investigating the role of TH in various physiological and pathological processes, driving advancements in the fields of neuroscience, neurology, and drug discovery.
Product Name:
Tyrosine Hydroxylase Rabbit Polyclonal Antibody
SKU:
CAB12756
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 411-528 of human Tyrosine Hydroxylase (NP_954986.2).
axon, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytosol, dendrite, mitochondrion, neuron projection, nucleus, perikaryon, perinuclear region of cytoplasm, smooth endoplasmic reticulum, synaptic vesicle, terminal bouton
Calculated MW:
59kDa
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
7054
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Tyrosine Hydroxylase Rabbit pAb (CAB12756) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
