TH (Ab-19) Antibody (PACO23605)
- SKU:
- PACO23605
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
TH (Ab-19) Antibody (PACO23605)
The TH-AB-19 Antibody (PAC023605) is a polyclonal antibody intended for research involving the TH-AB-19 protein. This protein is known for its role in immune regulation, specifically in inhibiting immune responses. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the TH-AB-19 protein, it enables detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.The TH-AB-19 protein, also referred to as an immune inhibitory molecule, plays a crucial role in maintaining immune homeostasis by regulating inflammation and suppressing allergic reactions.
Its involvement in immune response modulation makes it a key target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Knowledge of the function of TH-AB-19 is essential for the development of therapies that either harness or modify immune function in these disease contexts.
| Antibody Name: | TH (Ab-19) Antibody (PACO23605) |
| Antibody SKU: | PACO23605 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized non-phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of serine 19 (A-V-S(p)-E-Q). |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 3T3 cells treated with Forskolin (40nM, 30min), using Tyrosine Hydroxylase (Ab-19) antibody. |
 | Immunofluorescence analysis of HuvEc cells, using Tyrosine Hydroxylase (Ab-19) antibody. |
 | Immunohistochemical analysis of paraffin-embedded human brain tissue using Tyrosine Hydroxylase (Ab-19) antibody. |
| Background: | Plays an important role in the physiology of adrenergic neurons. |
| Synonyms: | EC 1.14.16.2; TH isoform 3; TH isoform a; TH-4; TY3H |
| UniProt Protein Function: | TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Protein type: Endoplasmic reticulum; Oxidoreductase; Vesicle; Amino Acid Metabolism - tyrosine; Mitochondrial; EC 1.14.16.2Chromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal buttonMolecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activityBiological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perceptionDisease: Segawa Syndrome, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q2M3B4 |
| NCBI GenInfo Identifier: | 88900501 |
| NCBI Gene ID: | 7054 |
| NCBI Accession: | NP_954986.2 |
| UniProt Secondary Accession: | Q2M3B4,Q0PWM2, Q0PWM3, Q15585, Q15588, Q15589, Q2M3B4 B7ZL70, B7ZL73 |
| UniProt Related Accession: | Q2M3B4,P07101 |
| Molecular Weight: | |
| NCBI Full Name: | tyrosine 3-monooxygenase isoform a |
| NCBI Synonym Full Names: | tyrosine hydroxylase |
| NCBI Official Symbol: | THÂ Â |
| NCBI Official Synonym Symbols: | TYH; DYT14; DYT5b  |
| NCBI Protein Information: | tyrosine 3-monooxygenase |
| UniProt Protein Name: | Tyrosine 3-monooxygenase |
| UniProt Synonym Protein Names: | Tyrosine 3-hydroxylase; TH |
| Protein Family: | |
| UniProt Gene Name: | THÂ Â |
| UniProt Entry Name: | TY3H_HUMAN |
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