The TGM5 Polyclonal Antibody (CAB7039) is a valuable tool for researchers studying the transglutaminase 5 (TGM5) protein, which plays a key role in various cellular processes including differentiation and apoptosis. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.TGM5 is a member of the transglutaminase enzyme family and is involved in the formation of cross-links between proteins, contributing to the structural integrity of tissues such as the skin and hair.
Dysregulation of TGM5 has been linked to diseases like celiac disease and dermatitis herpetiformis, highlighting its importance in maintaining tissue homeostasis.By targeting the TGM5 protein, researchers can gain insights into its function and potential as a therapeutic target for diseases associated with its dysregulation. The TGM5 Polyclonal Antibody (CAB7039) provides a reliable tool for detecting and analyzing TGM5 expression in various cell types, thereby advancing research in dermatology, gastroenterology, and other fields related to skin and tissue health.
Product Name:
TGM5 Rabbit Polyclonal Antibody
SKU:
CAB7039
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 461-720 of human TGM5 (NP_963925.2).
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.
Purification Method:
Affinity purification
Gene ID:
9333
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with TGM5 using TGM5 Rabbit pAb (CAB7039) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
