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TGM3 Polyclonal Antibody

SKU:
CAB24495
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
€129 - €359
Frequently bought together:

Description

TGM3 Polyclonal Antibody (CAB24495)

The TGM3 Polyclonal Antibody is a powerful tool for researchers studying transglutaminase 3 (TGM3) protein in various biological samples. This antibody, raised in rabbits, is highly specific to human TGM3 and is validated for use in Western blot applications. By specifically binding to the TGM3 protein, researchers can accurately detect and analyze TGM3 levels in different cell types.TGM3 is a key enzyme involved in various biological processes, including skin barrier function, epidermal differentiation, and wound healing.

Dysregulation of TGM3 has been implicated in skin disorders, such as psoriasis and atopic dermatitis, making it an important target for research in dermatology and skin biology.Overall, the TGM3 Polyclonal Antibody is a valuable tool for researchers looking to understand the role of TGM3 in skin biology and disease. Its high specificity and sensitivity make it an ideal choice for studies aiming to elucidate the molecular mechanisms underlying skin disorders and potential therapeutic interventions.

Product Name:TGM3 Polyclonal Antibody
Product Code:CAB24495
Reactivity:Human, Mouse
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:1000-1:5000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293T, 293T-TGM35-His(C)
Cellular Location:cytoplasm, extracellular exosome

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 291-480 of human TGM3 (NP_003236.3).
Sequence:SRVIT NFNSA HDTDR NLSVD VYYDP MGNPL DKGSD SVWNF HVWNE GWFVR SDLGP SYGGW QVLDA TPQER SQGVF QCGPA SVIGV REGDV QLNFD MPFIF AEVNA DRITW LYDNT TGKQW KNSVN SHTIG RYIST KAVGS NARMD VTDKY KYPEG SDQER QVFQK ALGKL KPNTP FAATS SMGLE TEEQE
Synonyms:TGM3, TGE, UHS2, transglutaminase 3
Calculated MW:76kDa
Observed MW:70kDa

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