UniProt Protein Function: | TGIF2: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Belongs to the TALE/TGIF homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 20q11.23Cellular Component: nucleoplasm; nucleusBiological Process: negative regulation of transcription from RNA polymerase II promoter |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q9GZN2 |
NCBI GenInfo Identifier: | 27805750 |
NCBI Gene ID: | 60436 |
NCBI Accession: | Q9GZN2.1 |
UniProt Secondary Accession: | Q9GZN2,B2R9U3, E1P5T9, H0YNI0 |
UniProt Related Accession: | Q9GZN2 |
Molecular Weight: | 17,908 Da |
NCBI Full Name: | Homeobox protein TGIF2 |
NCBI Synonym Full Names: | TGFB induced factor homeobox 2 |
NCBI Official Symbol: | TGIF2Â Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | homeobox protein TGIF2 |
UniProt Protein Name: | Homeobox protein TGIF2 |
UniProt Synonym Protein Names: | 5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2 |
Protein Family: | Homeobox protein |
UniProt Gene Name: | TGIF2Â Â |
UniProt Entry Name: | TGIF2_HUMAN |