The TGIF2 Polyclonal Antibody (PAC053190) is a valuable tool for researchers studying the TGIF2 protein, a transcriptional repressor involved in various cellular processes. This antibody, produced in the rabbit, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the TGIF2 protein, this antibody enables precise detection and analysis in a range of cell types, making it an essential component for investigations in molecular biology and cancer research.
TGIF2 plays a crucial role in gene regulation, particularly in the context of cell proliferation, differentiation, and development. Its involvement in various signaling pathways underscores its significance in cancer progression and other diseases. By studying the function of TGIF2, researchers can gain valuable insights into the mechanisms underlying these conditions, paving the way for the development of targeted therapies and treatment strategies.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO53190 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO53190 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-β activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
TGIF2: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Belongs to the TALE/TGIF homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 20q11.23Cellular Component: nucleoplasm; nucleusBiological Process: negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
